Over 500 million adults have diabetes worldwide and approximately 37 million adults have diabetes in the U.S.
WHAT IS DIABETIC EYE DISEASE?
High blood sugar levels due to diabetes cause damage to many parts of the body, including the small blood vessels in the eye.
Diabetic retinopathy and diabetic macular edema are two leading complications that affect patients with diabetes – both can lead to vision loss and blindness if left untreated.
Diabetic Retinopathy
Tap the image to see how DR affects the eye
Tap the image to see how DR affects the eye
Hover over the image to see how DR affects the eye
About 30% of adults with diabetes have diabetic retinopathy (DR). DR is a progressive disease that occurs when damaged blood vessels leak blood and fluid into the retina, the sensitive tissue in the back of the eye that helps process visual information.
About 30% of adults with diabetes have diabetic retinopathy (DR). DR is a progressive disease that occurs when damaged blood vessels leak blood and fluid into the retina, the sensitive tissue in the back of the eye that helps process visual information.
About 30% of adults with diabetes have diabetic retinopathy (DR). DR is a progressive disease that occurs when damaged blood vessels leak blood and fluid into the retina, the sensitive tissue in the back of the eye that helps process visual information.
Diabetic Retinopathy
Tap the image to see how DR affects the eye
Tap the image to see how DR affects the eye
Hover over the image to see how DR affects the eye
About 30% of adults with diabetes have diabetic retinopathy (DR). DR is a progressive disease that occurs when damaged blood vessels leak blood and fluid into the retina, the sensitive tissue in the back of the eye that helps process visual information.
About 30% of adults with diabetes have diabetic retinopathy (DR). DR is a progressive disease that occurs when damaged blood vessels leak blood and fluid into the retina, the sensitive tissue in the back of the eye that helps process visual information.
About 30% of adults with diabetes have diabetic retinopathy (DR). DR is a progressive disease that occurs when damaged blood vessels leak blood and fluid into the retina, the sensitive tissue in the back of the eye that helps process visual information.
Diabetic Macular Edema
Tap the image to see how DME affects the eye
Tap the image to see how DME affects the eye
Hover over the image to see how DME affects the eye
Diabetic macular edema (DME) is a complication of DR and can occur at any stage of DR. It occurs when leaked blood and fluid accumulate in the macula, the region within the retina responsible for clear central vision and causes it to swell (edema). This can lead to vision loss and blindness if left untreated.
Diabetic macular edema (DME) is a complication of DR and can occur at any stage of DR. It occurs when leaked blood and fluid accumulate in the macula, the region within the retina responsible for clear central vision and causes it to swell (edema). This can lead to vision loss and blindness if left untreated.
Diabetic macular edema (DME) is a complication of DR and can occur at any stage of DR. It occurs when leaked blood and fluid accumulate in the macula, the region within the retina responsible for clear central vision and causes it to swell (edema). This can lead to vision loss and blindness if left untreated.
Diabetic Macular Edema
Tap the image to see how DME affects the eye
Tap the image to see how DME affects the eye
Hover over the image to see how DME affects the eye
Diabetic macular edema (DME) is a complication of DR and can occur at any stage of DR. It occurs when leaked blood and fluid accumulate in the macula, the region within the retina responsible for clear central vision and causes it to swell (edema). This can lead to vision loss and blindness if left untreated.
Diabetic macular edema (DME) is a complication of DR and can occur at any stage of DR. It occurs when leaked blood and fluid accumulate in the macula, the region within the retina responsible for clear central vision and causes it to swell (edema). This can lead to vision loss and blindness if left untreated.
Diabetic macular edema (DME) is a complication of DR and can occur at any stage of DR. It occurs when leaked blood and fluid accumulate in the macula, the region within the retina responsible for clear central vision and causes it to swell (edema). This can lead to vision loss and blindness if left untreated.
Diabetic Retinopathy
Tap the image to see how DR affects the eye
Tap the image to see how DR affects the eye
Hover over the image to see how DR affects the eye
About 30% of adults with diabetes have diabetic retinopathy (DR). DR is a progressive disease that occurs when damaged blood vessels leak blood and fluid into the retina, the sensitive tissue in the back of the eye that helps process visual information.
About 30% of adults with diabetes have diabetic retinopathy (DR). DR is a progressive disease that occurs when damaged blood vessels leak blood and fluid into the retina, the sensitive tissue in the back of the eye that helps process visual information.
About 30% of adults with diabetes have diabetic retinopathy (DR). DR is a progressive disease that occurs when damaged blood vessels leak blood and fluid into the retina, the sensitive tissue in the back of the eye that helps process visual information.
Diabetic Macular Edema
Tap the image to see how DME affects the eye
Tap the image to see how DME affects the eye
Hover over the image to see how DME affects the eye
Diabetic macular edema (DME) is a complication of DR and can occur at any stage of DR. It occurs when leaked blood and fluid accumulate in the macula, the region within the retina responsible for clear central vision and causes it to swell (edema). This can lead to vision loss and blindness if left untreated.
Diabetic macular edema (DME) is a complication of DR and can occur at any stage of DR. It occurs when leaked blood and fluid accumulate in the macula, the region within the retina responsible for clear central vision and causes it to swell (edema). This can lead to vision loss and blindness if left untreated.
Diabetic macular edema (DME) is a complication of DR and can occur at any stage of DR. It occurs when leaked blood and fluid accumulate in the macula, the region within the retina responsible for clear central vision and causes it to swell (edema). This can lead to vision loss and blindness if left untreated.
EARLY DETECTION AND TREATMENT IS IMPERATIVE
DR progresses in stages and can do so quickly. Even if no visual symptoms are present, damage is occurring in the eye that can lead to vision-threatening complications, such as DME, at any time.
TODAY’S CHALLENGES
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Tap the tiles to see more information
HOW KODIAK CAN HELP
Kodiak’s Antibody Biopolymer Conjugate (ABC) medicines are designed to provide patients with DR and DME long-interval dosing and greater therapeutic benefit than today’s therapies.
Tarcocimab tedromer, Kodiak’s lead investigational medicine in Phase 3 clinical trials for NPDR and DME, is designed to provide twice yearly dosing for the majority of patients. Learn more.
KSI-501, our second investigational medicine in Phase 1 clinical study, is a first-in-class bispecific ABC that is designed to address the concurrent inflammation and blood vessel leakage in DR and DME. Learn more.
REFERENCES
- IDF Diabetes Atlas. International Diabetes Federation. Accessed May X, 2023. https://diabetesatlas.org/
- National Diabetes Statistics Report. Centers for Disease Control and Prevention. Updated June 29, 2022. Accessed May X, 2023. https://www.cdc.gov/diabetes/data/statistics-report/index.html
- Diabetes and Vision Loss. Centers for Disease Control and Prevention. Accessed May 19, 2023. https://www.cdc.gov/diabetes/managing/diabetes-vision-loss.html
- Lee et al. Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye and Vis 2. 2015; 17. doi: https://doi.org/10.1186/s40662-015-0026-2.
- How to Promote Eye Health for People With Diabetes. Centers for Disease Control and Prevention. Updated March 3, 2022. Accessed May X, 2023. https://www.cdc.gov/diabetes/professional-info/health-care-pro/diabetes-eye-health.html
- Bressler et al. Persistent Macular Thickening Following Intravitreous Aflibercept, Bevacizumab, or Ranibizumab for Central-Involved Diabetic Macular Edema With Vision Impairment. JAMA Ophthalmol. 2018; 136(3): 257-269. doi:10.1001/jamaophthalmol.2017.6565